Abstract
Developing a deeper understanding of biological components of sperm is essential to improving cryopreservation techniques and reproductive technologies. To fully ascertain the functional determinants of fertility, lipidomic methods have come to the forefront. Lipidomics is the study of the lipid profile (lipidome) within a cell, tissue, or organism and provides a quantitative analysis of the lipid content in that sample. Sperm cells are composed of various lipids, each with their unique contribution to the overall function of the cell. Lipidomics has already been used to find new and exciting information regarding the fatty acid content of sperm cells from different species. While the applications of lipidomics are rapidly evolving, gaps in the knowledge base remain unresolved. Current limitations of lipidomics studies include the number of available samples to analyze and the total amount of cells within those samples needed to detect changes in the lipid profiles across different subjects. The information obtained through lipidomics research is essential to systems and cellular biology. This review provides a concise analysis of the most recent developments in lipidomic research. This scientific resource is important because these developments can be used to not only combat the reproductive challenges faced when using cryopreserved semen and artificial reproductive technologies in livestock such as cattle, but also other mammals, such as humans or endangered species.
Highlights
Fertility—An Economically Vital TraitMale fertility may be defined as the ability of a sperm cell to fertilize an oocyte and support development to produce viable offspring
Lipidomics is the study of the lipid profile within a cell, tissue, or organism and provides a quantitative analysis of the lipid content in the sample being studied
There is a need for more detailed lipidomics studies utilizing sperm from livestock with distinct phenotypes of economically important traits such as sperm freezability and male fertility
Summary
Lipidomics has already been used to find new and exciting information regarding the fatty acid content of sperm cells from different species. Current limitations of lipidomics studies include the number of available samples to analyze and the total amount of cells within those samples needed to detect changes in the lipid profiles across different subjects. This review provides a concise analysis of the most recent developments in lipidomic research. This scientific resource is important because these developments can be used to combat the reproductive challenges faced when using cryopreserved semen and artificial reproductive technologies in livestock such as cattle, and other mammals, such as humans or endangered species
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have