Abstract
Tuberculosis (TB) drug-development strategies, a wide range of candidate host-directed therapies (HDT)s-including new and repurposed drugs, biologics, and cellular therapies-have been proposed to accelerate eradication of infection and overcome the problems associated with current treatment regimens. By investigating the interaction between macrophages and the intracellular parasite Toxoplasma gondii (T. gondii), we uncovered that infection-induced signaling pathways suggest possibilities for the development of novel therapeutic modalities for TB that target the intracellular signaling pathways permitting the replication of Mycobacterium tuberculosis (MTB).
Highlights
Tuberculosis (TB) drug-development strategies, a wide range of candidate host-directed therapies (HDT)sincluding new and repurposed drugs, biologics, and cellular therapies-have been proposed to accelerate eradication of infection and overcome the problems associated with current treatment regimens
By investigating the interaction between macrophages and the intracellular parasite Toxoplasma gondii (T. gondii), we uncovered that infection-induced signaling pathways suggest possibilities for the development of novel therapeutic modalities for TB that target the intracellular signaling pathways permitting the replication of Mycobacterium tuberculosis (MTB)
We uncovered that T. gondii dense granule antigen (GRA) 7/MyD88-dependent NF-κB activation is essential for the activation of TNF receptor-associated factor 6 (TRAF6) and reactive oxygen species generation, and enhances the release of inflammatory mediators
Summary
Tuberculosis (TB) drug-development strategies, a wide range of candidate host-directed therapies (HDT)sincluding new and repurposed drugs, biologics, and cellular therapies-have been proposed to accelerate eradication of infection and overcome the problems associated with current treatment regimens. Advancing host-directed therapy for tuberculosis: new therapeutic insights from the Toxoplasma gondii Department of Molecular and Life Science, Hanyang University, Ansan 15588, S.
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