Abstract
C-type lectin-like receptor-2 (CLEC-2) is a nonclassical C-type lectin receptor, which is mainly expressed on platelets and granulocytes. Under stimulation of the snake venom protein rhodocytin and transmembrane sialoglycoprotein podoplanin, it can form a dimer through YXXL motif in the cytosolic tail, leading to a syk-dependent signaling pathway. Recent studies demonstrated that CLEC-2 plays an important role in platelet aggregation, tumor metastasis, thrombotic development, as well as HIV dissemination. Therefore, Further study of CLEC-2 may provide information on the clinical treatment of the diseases related with platelet. Key words: C-type lectin receptor; C-type lectin-like receptor-2
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
