Abstract
In view of the highly increased prevalence of papillary thyroid carcinoma (PTC) year by year, it is of great importance to explore new molecular targets for anticancer strategies. Emerging evidence indicates that circular RNAs (circRNAs), characterized by a closed-loop structure and high stability, play important roles in tumorigenesis and development of human cancer by regulating multiple complex biological processes, such as cellular proliferation, metastasis, and metabolism. A comprehensive understanding of the roles of circRNAs will facilitate the development of promising future therapeutic strategies for treating cancers, including PTC. In this paper, we review the profile of circRNA in PTC, its regulatory roles, and the pathological mechanism as well as their related clinical significance. In addition, challenges of this specific field are discussed.
Highlights
Thyroid cancer (TC) is the most prevalent endocrine malignancy, accounting for nearly one third of the total head and neck malignancies globally (1, 2)
Previous research have profiled the circRNAs expression of papillary thyroid carcinoma (PTC) and have found significantly differentiated circRNAs in PTC compared with normal thyroid tissue, which may be involved in the pathogenesis of PTC
Based on gain- and loss-function experiments in vivo and in vitro, each identified circRNA displays significantly altered tumor cell biological behavior or cell phenotype in PTC cell lines, such as cell proliferation, cell cycle, apoptosis, migration, and invasion (Table 1), suggesting that the particular circRNA may act as an oncogenic driver or a tumor suppressor
Summary
Reviewed by: Jason David Prescott, Johns Hopkins Medicine, United States Marialuisa Appetecchia, Istituti Fisioterapici Ospitalieri (IRCCS), Italy. In view of the highly increased prevalence of papillary thyroid carcinoma (PTC) year by year, it is of great importance to explore new molecular targets for anticancer strategies. Emerging evidence indicates that circular RNAs (circRNAs), characterized by a closedloop structure and high stability, play important roles in tumorigenesis and development of human cancer by regulating multiple complex biological processes, such as cellular proliferation, metastasis, and metabolism. A comprehensive understanding of the roles of circRNAs will facilitate the development of promising future therapeutic strategies for treating cancers, including PTC. We review the profile of circRNA in PTC, its regulatory roles, and the pathological mechanism as well as their related clinical significance.
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