Abstract
Bacterial ghost(BG) is an empty bacterial envelope of gram-negative bacteria devoid of cytoplasmic content,and produced by controlled expression of bacteriophage PhiX174 lysis gene E.BG keeps intact bacterial outer membrane structure,such as flagella,LPS and outer membrane proteins,making bacterial easy to adherence to the human or animal cell receptors,so it can be used as vaccines without adjuvant to induce strong humoral immune response and cellular immune response.BG has many spaces,such as the outer membrane,the periplasmic space and the inner membrane to load other substance.BG also can be used as DNA,antigen and drugs delivery vector as it exhibits potency with regard to target antigens and large capacity compared to conventional approaches.In addition,BG can be provided with a foreign antigen,nucleic acid or other ingredients to construct combined vaccine for human or animal health services.BG has wide application prospect in the prevention and treatment of disease.
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