Advances of radiobiology in stereotactic body radiation therapy

Abstract

RT can not only give the tumor a high dose of irradiation, but also protect the surrounding normal tissue as much as possible. SBRT is consistent with the general law of the dose-effect of tumor radiation biology, which the high dose radiation will increase the damage to the tumor. Compared to conventional radiation therapy, SBRT has less fractions (1-5), and higher single dose (8-30 Gy). The LQ (Linear-Quadratic) model which applied in the multi-fractions conventional radiation therapy may not evaluate the biological effect accurately in large dose radiation. Some scholars proposed USC (universal survival curve), LQL (linear-quadratic-linear), gLQ (generalized-linear-quadratic) modified models to intent to predict the radiobiology better in SBRT.SBRT has become one of the important methods to treat the tumor in Lung, Live, Spine and other organs. Advances in radiation biology can further explore the clinical application of SBRT, which contributes to improve the therapeutic effect of tumor radiotherapy Key words: Stereotactic body radiation therapy; Radiobiology; Advance