Abstract
Biliary atresia(BA) is a destructive inflammatory obliterative cholangiopathy of neonates affecting both intrahepatic and extrahepatic bile ducts.BA is more common in east Asia.Genetic susceptibility, viral infections, and immune dysregulation may be related to BA, but immune dysregulation may play a key hole in the pathogenesis of BA.A current view of the pathogenesis of BA is that it may involve both a primary perinatal hepatobiliary viral infection and a secondary generation of an autoimmune-mediated bile duct epithelial injury.The etiology of BA is unknown, but there is evidence for the involvement of immunologic dysregulation mechanisms, which will be discussed in this review. Key words: Biliary atresia; Mechanism; Immune dysregulation
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