Abstract
Psoriatic arthritis (PsA) is a common type of inflammatory arthritis found in up to 40% of patients with psoriasis. Although early diagnosis is important for reducing the risk of irreversible structural damage, there are no adequate screening tools for this purpose, and there are no clear markers of predisposition to the disease. Much evidence indicates that PsA disorder is complex and heterogeneous, where genetic and environmental factors converge to trigger inflammatory events and the development of the disease. Nevertheless, the etiologic events that underlie PsA are complex and not completely understood. In this review, we describe the existing data in PsA in order to highlight the need for further research in this disease to progress in the knowledge of its pathobiology and to obtain early diagnosis tools for these patients.
Highlights
Psoriatic arthritis (PsA), or the broader term psoriatic disease, refers to an inflammatory disorder that affects numerous organs, including the skin and joints
This and other observations indicate that PsA is a complex disease where interaction of multiple factors, environmental and random events, which occurs in genetically predisposed individuals, triggers pathological pathways that lead to the development of the disease [12]
From the results of this study, it can be concluded that the likely involvement of SIRT1 in the pathogenesis of PsA demonstrates how epigenetic mechanisms are closely related to inflammation and tissue damage
Summary
Psoriatic arthritis (PsA), or the broader term psoriatic disease, refers to an inflammatory disorder that affects numerous organs, including the skin and joints. It is associated with extra-articular manifestations and multiple comorbidities [1]. PsA is mainly characterized by stiffness, pain, swelling, and tenderness of the joints and their surrounding ligaments and tendons (dactylitis and enthesitis). The course of this disease is variable and unpredictable, ranging from mild and nondestructive joint involvement to a severe, debilitating, and erosive arthropathy [3]. The objective of this review is to bring together what has been described so far from genomics of PsA in order to encourage further research in this disease and other related pathologies such as ankylosing spondylitis (AS) to start creating evidence
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