Abstract
Background Ephs is the largest subfamily of receptor tyrosine kinases (RTKs) in the human genome,which binds to the ligand,Ephrins,to regulate many development processes,including tissue-border formation,re-angiogenesis,axon guidance,and synaptic plasticity.Recent studies indicate that EphrinBs/EphBs signaling regulates the nociceptive process.Objective Here we retrospectively summarized the mechanism of EphrinBs/EphBs signaling pathway in regulating the process of pain. Content A great deal of studies have shown that EphrinBs/EphBs signaling pathway modulates the development of nociceptive process through upregulating the excitability of nociceptive dorsal root ganglia and wide dynamic range neurons in spinal dorsal horn,producing central sensitization,and activating the downstream mitogen-activated protein kinase (MAPKs) pathway.Trend Clarifying the downstream mechanism of EphrinBs/EphBs signaling pathway in the nociceptive process will be helpful helpful to find a new potential target for the treatment of pain. Key words: EphrinBs/EphBs; Nociceptive process; Central sensitization; Mitogen-activated protein kinase
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Anesthesiology and Resuscitation
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
