Advances of Endothelial Progenitor Cells in the Development of Depression.

Nana Yang,Jielun Yu,Kaixuan Lv,Guohua Lu,Yaohui Tang,Linlin Zhang,Shiyu Sun,Chen Liang,Guangqing Duan

doi:10.3389/fncel.2021.608656

Abstract

Depression is a major psychological disease of human beings. With the severity of depression, it elevates the risk of cardiovascular disease (CVD), especially acute coronary syndrome (ACS), resulting in serious harm to human health. The number of endothelial progenitor cells (EPCs) is closely related to the development of depression. It has been reported that the number of peripheral blood EPCs in patients with depression was reduced. However, effects on the function of EPCs in depression are still unclear. This paper aims to analyze and summarize the research of EPCs in depression, and we envision that EPCs might act as a new target for evaluating the severity of depression and its complications.

Highlights

Depression is one of the most common psychological disorders which acts as the primary risk factor for suicide and cardiovascular disease (Shi et al, 2017)
CEPCs levels in blood had no significant difference in chronic mild stress (CMS) group, high-fat diet group, high-fat diet with CMS group, and the group of imipramine and pentoxifylline treatment
The results demonstrated that tumor necrosis factor-α (TNF-α) significantly reduced the quantity, capabilities of proliferation, migration and adhesion of endothelial progenitor cells (EPCs), with a negative correlation between the quantity and function of EPCs and concentration of TNF-α

Summary

Introduction

Depression is one of the most common psychological disorders which acts as the primary risk factor for suicide and cardiovascular disease (Shi et al, 2017). As a common disease detrimental to the physical and mental health of human beings, depression is prominently manifested as depressive symptoms, such as reduced activity, memory loss, fatigue, sleep disorders, self-abandonment and even suicide (Malhi and Mann, 2018). Scientists proposed a certain correlation between EPCs and depression (Dome et al, 2009; Di Stefano et al, 2014; Felice et al, 2015). It becomes the most eye-catching whether EPCs can serve as an indicator for the severity of depression

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Methods

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Conclusion