Abstract
Eukaiyotic translation initiation factor 4E(eIF4E) is a key factor initiate eukaryotic transla-tion. eIF4E has significant correlation with the carcinogenesis, cancer development and invasion, etc. Recent studies in breast cancer show that eIF4E is an important prognostic factor and associated with sensitivity of breast cancer cells to radiotherapy. eIF4E expression has a potential contribution to therapeutic strategy mak-ing, meanwhile, it is a promising effective target of breast cancer treatment. Key words: eIF4E; Breast neoplasms; Prognosis; Therapy
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