Advances of azide-alkyne cycloaddition-click chemistry over the recent decade

Abstract

Click chemistry is an approach that uses efficient and reliable reactions, such as Cu(I)-catalyzed azide−alkyne cycloaddition (CuAAC) to bind two molecular species. This versatile reaction is expected to become pivotal for meeting future challenges in organic chemistry. The impact of click chemistry is increasing tremendously day by day not only in the field of organic synthesis, but also in drug discovery efforts, polymer chemistry and in different disciplines of material science. This review describes the general features and applications of CuAAC in organic synthesis (CuAAC-OS), highlighting the suitability of this kind of reaction for peptides, nucleotides, small molecules, supramolecular structures, and polymers among others. Herein, the emerging methodologies employing click chemistry with a brief description of each has been presented in a best possible systematic manner with the hope that this review would satisfy the workers involved directly or indirectly to the fields, which employ click method for different purposes.