Advances into the Epigenetic Regulation by DNA Methylation in Non-Alcoholic Fatty Liver Disease

Teresa Rubio- Tomás

doi:10.31031/gmr.2021.06.000628

Abstract

Gastroenterology Medicine & Research Advances into the Epigenetic Regulation by DNA Methylation in Non-Alcoholic Fatty Liver Disease Teresa Rubio-Tomás1,2* 1Institute for Biomedical Research August Pi and Sunyer (IDIBAPS), Spain 2School of Medicine, University of Crete, Greece *Corresponding author:Teresa Rubio- Tomás, Institute for Biomedical Research August Pi and Sunyer (IDIBAPS), Spain Submission: July 31, 2021;Published: August 12, 2021 DOI: 10.31031/GMR.2021.06.000628 ISSN 2637-7632Volume6 Issue1

Highlights

Non-Alcoholic Fatty Liver (NAFLD) is an etiology of chronic liver disease and can progress to steatohepatitis, cirrhosis and liver cancer, is increasing worldwide due to unhealthy lifestyle (i.e., Western diet, lack of physical exercise and subsequent obesity), among other factors
Many efforts are being done to understand the pathogenesis of NAFLD to stop this global pandemic and many alterations in epigenetic mechanisms have been detected during the course of the disease
In this mini-review I will focus on recent articles that explore the link between deregulation of DNA methylation, an important epigenetic mechanism, and NAFLD development and progression towards steatohepatitis, cirrhosis and liver cancer

Summary

Introduction

Non-Alcoholic Fatty Liver (NAFLD) is an etiology of chronic liver disease and can progress to steatohepatitis, cirrhosis and liver cancer, is increasing worldwide due to unhealthy lifestyle (i.e., Western diet, lack of physical exercise and subsequent obesity), among other factors. It is important to unravel the molecular mechanisms governing the development of NAFLD and its progressing to more advanced stages, including cancer [2] In this sense, the relevance of epigenetics has been recently explored since the importance of epigenetic regulation in healthy liver and liver diseases is nowadays undoubtable [3,4]

DNA methylation in NAFLD

Conclusion and Further Directions