Advances in virtual screening techniques for anti-viral drug design: A computational perspective

Abstract

With the outbreak of the novel coronavirus, which has been found to mutate almost once a week, future viruses may mutate faster than we think. To deal with the mutation of the virus as soon as possible, the development of new drugs should be accelerated. The traditional drug research and development cycle is long, the cost is high, and the human resource consumption is large. Virtual screening technology has gradually become an indispensable link in the research and development of new drugs because of its high efficiency and low cost. This paper introduces the discovery, structure, symptoms and pathogenesis of 5 viruses (HIV, HBV, HCV, Ebola Virus, Coronavirus), and summarizes the application cases of virtual screening technology in the research and development of new antiviral drugs in recent years, to provide a reference for researchers.