Abstract
Gellan Gum (GG) is a large, naturally occurring, linear polysaccharide with a similar structure and biological properties to the extracellular matrix. It's appropriate as a matrix material for the development of different composite materials due to its biocompatibility, biodegradability, and injectability. Hydrogels made from GG have found various applications in the field of Tissue Engineering (TE) in recent years after being mixed with a variety of other organic and inorganic components. These composites are considered multifunctional developing biomaterials because of their impressive mechanical capabilities, biocompatibility, low cytotoxicity, etc. This review focuses on the emerging advances of GG-based hydrogels in TE, providing an overview of the applications of different types of GG-based composite materials in bone TE, cartilage TE, nervous TE, retina TE, and other fields. Moreover, the investigations of GG-based hydrogels as bioink components for 3D bioprinting in TE will be elucidated. This review offers general guidance for the development of biomaterials related to GG, as well as ideas for future clinical diagnosis and treatment.
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