Abstract
Na+/K+ ATPase activity is highly regulated in the renal proximal tubules by several hormones including PTH and dopamine. Both parathyroid hormone (PTH) and dopamine decrease Na+/K+ ATPase activity and expression by similar yet distinct signaling mechanisms. The role of PTH in regulation of Na+/K+ ATPase in renal proximal tubules is not very well studied. In contrast, dopamine regulation of Na+/K+ ATPase is extensively studied. This chapter focuses on the differential regulation of Na+/K+ ATPase by PTH and dopamine in renal proximal tubule cells.
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