Advances in the Understanding of Renal Proximal Tubular Na+/K+ ATPase Regulation by Parathyroid Hormone and Dopamine

Syed J Khundmiri,Rebecca D Murray,Eleanor D Lederer

doi:10.1007/978-3-319-24750-2_22

Advances in the Understanding of Renal Proximal Tubular Na+/K+ ATPase Regulation by Parathyroid Hormone and Dopamine

Syed J Khundmiri, Rebecca D Murray + Show 1 more

https://doi.org/10.1007/978-3-319-24750-2_22

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Publication Date: Dec 16, 2015

Affiliation: Howard University, University of Louisville

#Parathyroid Hormone #Regulation Of Na + Show 8 more

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Abstract

Na+/K+ ATPase activity is highly regulated in the renal proximal tubules by several hormones including PTH and dopamine. Both parathyroid hormone (PTH) and dopamine decrease Na+/K+ ATPase activity and expression by similar yet distinct signaling mechanisms. The role of PTH in regulation of Na+/K+ ATPase in renal proximal tubules is not very well studied. In contrast, dopamine regulation of Na+/K+ ATPase is extensively studied. This chapter focuses on the differential regulation of Na+/K+ ATPase by PTH and dopamine in renal proximal tubule cells.

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