Advances in the study on ubiquitination modification in the development of hypertension

Abstract

Hypertension is the most common chronic disease, which predisposes to stroke, aneurysm, heart failure, myocardial infarction, kidney damage, and other important complications. For this reason, the pathogenesis of hypertension is the research hotspot of current study. Ubiquitination modification is an important protein post-translational modification, which can promote protein degradation through proteasome pathway, and is one of the most important mechanisms regulating the level and function of cellular protein. Ubiquitination is a cascade of enzymatic reactions, in which ubiquitin E3 ligases are the most important enzymes in the ubiquitination process. It determines the specificity of the substrate. Many substrates of ubiquitin E3 ligases are important kidney ion channel proteins, such as ENaC, NCC, NHE3 and so on. Ubiquitination can regulate the degradation of these proteins, and affect their activity and membrane localization, thus affect the kidney water and electrolyte balance, which is closely related to the occurrence of hypertension. Key words: Ubiquitination; Ubiquitin E3 ligase; NEDD4L; Hypertension