Abstract
The skin is the largest organ of the human body and the first part to be damaged by external impact and injury. Macrophages, as the main immune cells of the body, are involved in the whole process of trauma inflammation, repair, regeneration, and fibrosis, and with the study of their molecular pathway mechanisms promoting macrophage polarization becoming clearer, it also brings undeniable research progress for molecular targeting therapy in later stages of clinical practice. This review summarizes the molecular mechanisms associated with the typing of macrophages, the various stages of repair during organismal injury, and macrophages, thus bringing new thinking to macrophage polarization for wound healing.
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