Abstract
Diabetes mellitus is a group of metabolism-related diseases characterized by elevated plasma glucose levels, and the course of diabetes mellitus is closely linked to the development of diabetes-related complications, which can be life-threatening due to poor glycemic control. Exosomes are small vesicles that encapsulate intracellular molecules and are composed of a variety of bioactive proteins, lipids and nucleic acids (including microRNAs, lncRNAs, and circ-RNAs), and recent studies have increasingly shown that miRNAs in exosomes are an important mode of intercellular and intertissued communication and play a key role in the development and progression of various diseases. This review presents the progress of the application of exosomal miRNAs in type 1 diabetes mellitus (T1DM), type 2 diabetes mellitus (T2DM), and diabetes-related complications.
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