Advances in the role of adenoid hypertrophy in the pathogenesis of otitis media with effusion in children

Abstract

Adenoid hypertrophy(AH) and otitis media with effusion (OME) are both common diseases in pediatric otorhinolaryngology and are often associated with each other. Children are often diagnosed with otitis media with effusion and adenoid hypertrophy(OME/AH). Adenoids are immune lymphoid tissues of children's upper respiratory tract, and are important barriers against upper respiratory tract infections.During an upper respiratory tract infection,bacteria or viruses repeatedly stimulate immune lymphoid tissue to cause hyperplasia,and pathological hypertrophy is often accompanied by OME and other related symptoms.In recurrent or chronic OME, hyperproliferative adenoids are usually excised indicating that the two diseases may have a certain correlation. Recently,more and more studies have shown that AH plays an important role in the pathogenesis of OME in children. This article elucidates the role of AH in the pathogenesis of childhood OME from adenoid mechanical obstruction,adenoid bacterial and bacterial biofilm, adenoid local immune regulation, and IgE-mediated allergic reaction.