Abstract

Mucosal vaccination becomes a research focus in recent years.It has many advantages,such as inducing both local mucosal and systemic immune responses and having good compliance.But most antigens administered by mucosal routes easily cause immune tolerance,which hinders further development of mucosal vaccines.In order to overcome these difficulties,a number of mucosal adjuvants and delivery systems have been designed to enhance mucosal and systemic immune responses.This article describes main advances in research of mucosal adjuvants and delivery systems. Key words: Immunity, mucosal; Adjuvants, immunologic; Delivery system

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