Abstract
Neural tube defect(NTD)is a complex and serious birth defect in the central nervous system.The etiology of NTD is multifactorial, involving the combined action of both genetic and environmental factors.Maternal nutrition is a significant environmental factor in NTD etiology, including vitamin B, folic acid, choline, and so on.Inositol, a substance of vitamin B, is closely related to embryonic development and NTD.Studies have found out that inositol supplement can prevent folic acid-resistant NTD and the key genes in its metabolic pathways play an important role in NTD occurrence.Therefore, this article reviews the inositol metabolic pathways and the relationship between its key genes and NTD, providing references for the depth study of NTD pathogenesis and prevention. Key words: Neural tube defect; Inositol; Gene
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