Abstract
Depression in the elderly is a complex mental disease. The influencing factors includes negative life events, age, gender, physical illness, economic status, personal vulnerability, social support, etc. The brain background constituted by these factors is more susceptible to the influence of stress, leading to pathological changes in the physiological structure, such as brain structural changes, vascular injury, inflammatory mechanisms, neuroendocrine changes, etc. This peper aims to review the recent advances in the etiology and pathogenesis of senile depression in order to provide reference for clinical treatment and prevention of depression in the elderly. Key words: Aged; Depression; Pathogenesis; Research progress
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