Advances in the etiology and pathogenesis of rosecea

Abstract

Rosacea is a chronic inflammatory skin disease occurring in the central region of the face with a predilection for middle-aged people.It is usually characterized by flushing,permanent erythema,telangiectasia,papules,rhinophyma,sometimes with the involvement of eyes.Its etiology and pathogenesis have not been completely understood.Past hypotheses on its pathogenesis were mainly focused on ultraviolet radiation,vascular abnormalities and infection by microorganisms such as Demodex folliculorum,and it was believed that chronic ultraviolet radiation could destroy epidermal barrier and perivascular connective tissue,resulting in vascular abnormalities.More evidences are needed to support the role of microbes in the development of rosacea.Recent molecular studies have suggested that innate immune system,increased serine protease activity and abnormal expression of antimicrobial peptides are all involved in the pathogenesis of rosacea. Key words: Rosacea; Ultraviolet rays; Blood vessels; Microbiology; Immunity