Abstract
Polymorphous light eruption (PLE) is a chronic, idiopathic, common photoreactive disease associated with sunlight exposure. The etiology and pathogenesis of PLE are still unclear, and reported to be associated with genetic factors, ultraviolet ray-induced internal antigens and external photosensitive materials,immune function disturbance, et al. Recently, there have been increasing reports on the etiology and pathogenesis of PLE, which are mainly related to the direct exposure to ultraviolet B and ultraviolet A,accumulation of oxygen free radicals, delayed type hypersensitivity, cytokines and inherent factors. Besides, the transition of PLE to autoimmune diseases has been reported. Nowadays, it is an important task for clinicians to clarify the pathogenesis of PLE. Key words: Photosensitivity disorders; Etiology; Research
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