Abstract
Gastrointestinal neuroendocrine tumors are rare neoplasms that share a common histology and biochemical features yet differ widely in their natural histories. Recent advances in our understanding of the biology of these tumors have been helpful in designing diagnostic localization strategies, selecting patients for appropriate treatment, and developing novel therapeutic approaches. Gastrointestinal neuroendocrine tumors constitute approximately 2% of all malignant gastrointestinal tumors [1]. They are classically divided into the carcinoid tumors and the pancreatic islet cell tumors. Neuroendocrine tumors have been described as being comprised of APUD (amine-precursor uptake and decarboxylation) cells [2,3]
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