Advances in the detection of Treponema pallidum-specific IgM antibody

Abstract

Syphilis,a chronic infectious disease caused by Treponema pallidum,often has complicated manifestations.Syphilis is spread mainly through sexual transmission,sometimes by maternal-to-infant vertical transmission.The diagnosis and efficacy evaluation of syphilis are commonly based on laboratory examination,especially on serological antibody detection.It has been demonstrated that specific IgM antibody detection is a prospective means for the diagnosis of early syphilis,congenital syphilis,neurosyphilis and recurrent syphilis.This article describes the tests most commonly used for the deletion of Treponema pallMum-specific IgM antibody. Key words: Syphilis ; Immunoglobulin M antibody ; Treponema pauidum ; Diagnostic tests,routine ;