Abstract
Rho GTPases are a family of small GTPases, which acts as an important molecular switch in signal transduction and plays pivotal roles in many biological processes such as cell morphology, cytoskeleton reorganization, cell migration, cell cycle and apoptosis. Recent studies demonstrate that Rho GTPases show abnormal expression in diverse malignant tumors and participate in tumor invasion and metastasis by regulating the loss of epithelial polarity, the junction and adhesion between cells, cytoskeleton reorganization and cell motility, extracellular matrix remodeling and the ability to enter either the blood or the lymphatic vasculature. It is important to further investigate the function of Rho GTPases in tumor invasion and metastasis. Rho GTPases likely become new biomarkers to indicate tumor invasion and metastasis, and provide new targets for tumor therapy. Key words: Rho GTPases; Cancer; Invasion; Metastasis
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