Abstract
Chuanxiong Rhizoma (Chuan-Xiong, CX), the dried rhizome of Ligusticum chuanxiong Hort. (Umbelliferae), is one of the most popular plant medicines in the World. Modern research indicates that organic acids, phthalides, alkaloids, polysaccharides, ceramides and cerebrosides are main components responsible for the bioactivities and properties of CX. Because of its complex constituents, multidisciplinary techniques are needed to validate the analytical methods that support CX’s use worldwide. In the past two decades, rapid development of technology has advanced many aspects of CX research. The aim of this review is to illustrate the recent advances in the chemical analysis and biological activities of CX, and to highlight new applications and challenges. Emphasis is placed on recent trends and emerging techniques.
Highlights
Chuanxiong Rhizoma, the dried rhizome of Ligusticum chuanxiong Hort., known as Chuan-Xiong (CX) in folk medicine, and belonging to the Umbelliferae family, is one of the oldest and most popular herbal medicines in theWorld [1,2]
We have summarized the recent progress in the chemical analysis of CX
HPLC, HPLC-mass spectrometry (HPLC-MS) and gas chromatography-MS (GC-MS) are mostly used for CX analysis
Summary
World [1,2] It has been used for thousands of years in traditional Chinese, Japanese, and Korean folk medicine [3]. It was firstly cited as “Xiong-Qiong” in Shennong’s Classic of Materia Medica (200–300 A.D., Han Dynasty) an oldest Chinese herbal classical masterpiece [1,4]. Some studies have shown that both of them had antioxidative activities, through their high free radical scavenging ability, they may exert vascular relaxant effect, and inhibitory effects on DNA damage and apoptosis induced by ultraviolet B in mammalian cells [12,13,14] It is L. chuanxiong that is recorded by the Chinese Pharmacopoeia and applied commonly in China
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