Advances in the Application of Natural Products and the Novel Drug Delivery Systems for Psoriasis.

Jin Xie,Xuan Deng,Ming Yang,Pengfei Yue,Haozhou Huang,Li Han,Shengjie Huang,Junzhi Lin,Ding-Kun Zhang

doi:10.3389/fphar.2021.644952

Abstract

Psoriasis, an incurable autoimmune skin disease, is one of the most common immune-mediated disorders. Presently, numerous clinical research studies are underway, and treatment options are available. However, these treatments focus on improving symptoms of the disease and fail to achieve a radical cure; they also have certain toxic side effects. In recent years, natural products have increasingly gained attention because of their high efficiency and low toxicity. Despite their obvious therapeutic effects, natural products’ biological activity was limited by their instability, poor solubility, and low bioavailability. Novel drug delivery systems, including liposomes, lipospheres, nanostructured lipid carriers, niosomes, nanoemulsions, nanospheres, microneedles, ethosomes, nanocrystals, and foams could potentially overcome the limitations of poor water solubility and permeability in traditional drug delivery systems. Thus, to achieve a therapeutic effect, the drug can reach the epidermis and dermis in psoriatic lesions to interact with the immune cells and cytokines.

Highlights

Psoriasis is a chronic autoimmune skin disease that affects 2–5% of the world’s population (Sala et al, 2016)
Natural Products for Targetting Psoriasis an individual does not receive prompt and effective treatment, psoriasis can turn into a severe disease, with widespread plaques covering more than 10% of the body surface areas (Hawkes et al, 2017)
The clinical phenotypes of psoriasis are generally classified into the following types: plaque psoriasis, guttate psoriasis, pustular psoriasis, and erythrodermic psoriasis

Summary

Introduction

Psoriasis is a chronic autoimmune skin disease that affects 2–5% of the world’s population (Sala et al, 2016). Novel drug delivery systems (such as liposomes, lipospheres, nanostructured lipid carriers, niosomes, and nanoemulsions) have been developed to improve the skin penetration of natural products, impacting the immune cells in the epidermis or dermis and improving the therapeutic effects. A clinical anti-psoriasis drug, is usually applied topically in combination with tacrolimus, mometasone furoate, or calcitriol to reduce side effects and increase the permeability of the drug to the skin.

Results

Conclusion