Abstract
Antibiotic abuse is becoming increasingly serious and the potential for harm to human health and the environment has aroused widespread social concern. Aminoglycoside antibiotics (AGs) are broad-spectrum antibiotics that have been widely used in clinical and animal medicine. Consequently, their residues are commonly found in animal-derived food items and the environment. A simple, rapid, and sensitive detection method for on-site screening and detection of AGs is urgently required. In recent years, with the development of molecular detection technology, nucleic acid aptamers have been successfully used as recognition molecules for the identification and detection of AGs in food and the environment. These aptamers have high affinities, selectivities, and specificities, are inexpensive, and can be produced with small batch-to-batch differences. This paper reviews the applications of aptamers for AG detection in colorimetric, fluorescent, chemiluminescent, surface plasmon resonance, and electrochemical sensors for the analysis in food and environmental samples. This study provides useful references for future research.
Highlights
Aminoglycoside antibiotics (AGs) are a class of broad-spectrum antibiotics whose molecules are composed of an aminocyclitol and one or more amino sugar molecules (d-glucosamine, d-kanosamine) connected by glucoside bonds (Figure 1) [1,2]
This review focuses on aptamer sensors using colorimetric, fluorescent, chemiluminescent, surface plasma resonance (SPR), and electrochemical techniques for the detection of AGs
The extensive use and even abuse of antibiotics have posed a serious threat to the environment and food safety
Summary
Aminoglycoside antibiotics (AGs) are a class of broad-spectrum antibiotics whose molecules are composed of an aminocyclitol and one or more amino sugar molecules (d-glucosamine, d-kanosamine) connected by glucoside bonds (Figure 1) [1,2]. A rapid, sensitive, properties of nanomaterials, such as metal nanoparticles, carbon nanotubes, nanocomposite, and and inexpensive method should be established for the detection of AG residues in food and the nanostructuredmaterials, they have been widely used in aptasensing strategies. Due to the unique optical, electrochemical, and mechanical properties of nanomaterials, such as metal nanoparticles, carbon nanotubes, nanocomposite, and nanostructuredmaterials, they have been widely used in aptasensing strategies These nanomaterials are applied as catalytic tools, immobilization platforms, or as optical or electroactive labels in biosensor schemes in order to improve their performance [58].
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