Abstract
EDITORIAL article Front. Physiol., 02 July 2014Sec. Systems Biology Archive Volume 5 - 2014 | https://doi.org/10.3389/fphys.2014.00249
Highlights
The last two decades have generated numerous studies that show the close link between immune response and cancer progression in the mammalian system
They surveyed a depth of recent literature that points to the presence of breast cancer stem cells (CSCs), which are responsible to mediate metastasis and are resistant to both radiationand chemo-therapies
The classification of CSCs are currently based on the expression levels of cell surface markers CD44+CD24− and enzyme Aldehyde dehydrogenase (ALDH) activity, they note that the heterogeneity of single cancer cells makes this classification a nontrivial process
Summary
The last two decades have generated numerous studies that show the close link between immune response and cancer progression in the mammalian system. They surveyed a depth of recent literature that points to the presence of breast cancer stem cells (CSCs), which are responsible to mediate metastasis and are resistant to both radiationand chemo-therapies. The classification of CSCs are currently based on the expression levels of cell surface markers CD44+CD24− and enzyme Aldehyde dehydrogenase (ALDH) activity, they note that the heterogeneity of single cancer cells makes this classification a nontrivial process.
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