Abstract
Bronchopulmonary dysplasia(BPD)is a chronic lung disease of prematurity mainly affecting preterm infants with low birth weights, especially those treated with mechanical ventilation and oxygen therapy.There is no specific treatment for BPD until now.Administration of mesenchymal stem cells seems to be an promising novel treatment.Mesenchymal stem cell(MSC)can attenuate lung injury in an amount of animal experiments.But the mechanism is unclear yet.The best dose, timing and the application route of transplantation as the standard treatment strategy is still unresolved.The phase Ⅰclinical trail shows short-term safety and efficacy of MSC administration.Phase Ⅱ trails and long-term safety studies are under way.This review focuses on the recent achievement in treating BPD with MSC transplantation. Key words: Bronchopulmonary dysplasia; Mesenchymal stem cell
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