Abstract
NK/T-cell lymphoma(NTCL)can be classified into upper aerodigestive tract(UAT)NTCL and non-UAT NTCL. The Ann Arbor staging system is unsatisfactory for this lymphoma. A new staging system for NTCL is proposed:limited disease(stage Ⅰ/Ⅱ UAT-NTCL without local invasion)and extensive disease(stage Ⅰ/Ⅱ with local invasion or stage Ⅲ/Ⅳ disease of UAT NTCL, non-UAT NTCL). There is an ongoing debate regarding the use of the Ann Arbor staging and the International Prognostic Index for prognostic purposes in NK/T-cell lymphoma. Other factors, including tumor's local infiltration, Epstein-Barr virus, tumor biology and microenvironment, have also been found to affect the prognosis. Key words: Killer cells, natural; Lymphoma, T-cell; Staging; Prognosis
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