Advances in Research Related to the p38 MAPK/PTGS2 Signaling Pathway and Pathogenesis of Laryngeal Cancer: A Review

Abstract

Laryngeal cancer is a malignant tumor of the head and neck with clinical features of high recurrence and metastasis and a poor prognosis. The pathogenesis of laryngeal cancer is not clearly understood, but it is undoubtedly a complex developmental process involving multiple pathways and genes. Finding new ways to treat laryngeal cancer is particularly important as it is the second most common cancer of the head and neck, with many post-operative complications, poor quality of life and poor outcomes for patients with mid to latestage laryngeal cancer. The pathogenesis of laryngeal cancer is currently a hot topic of research. p38 mitogenactivated protein kinase/prostaglandin-endoperoxide synthase 2-related targets and signalling pathways have repeatedly been shown to play an important role in the development of tumours, including laryngeal cancer. With the continuous development of immunology, biochemistry and experimental techniques, it has become a current research trend to investigate the pathogenesis of laryngeal cancer at the molecular level. p38 mitogenactivated protein kinase and prostaglandin-endoperoxide synthase 2 have repeatedly been shown to play an important role in tumorigenesis and are also closely associated with the development of laryngeal cancer. This paper explores the potential association of p38 mitogen-activated protein kinase/prostaglandin-endoperoxide synthase 2 related targets and pathways with the development of laryngeal cancer in the context of the mechanisms of action of these pathways in a variety of tumors, with the aim of predicting possible targets for drug treatment of laryngeal cancer.