Advances in Research and Treatment on Patients with Alzheimer's disease Induced by Sleep disorders

Abstract

Alzheimer's disease (AD) is a disease characterized by memory impairment, loss of words and inability in emotional control that occurs in the early and intermediate stage of the end of our lives. A number of studies have shown that the incidence and severity of AD is higher in patients with sleep disorders than in healthy people. The pathogenic mechanism of AD is still inconclusive, while several hypotheses have been proposed according to its etiological characteristics: Some studies suggest that the β-amyloid protein hypothesis and the mechanism of abnormal phosphorylation of protein tau induced by sleep disorders may be the key factors leading to AD. This paper will summarize the mechanisms of AD induced by sleep disorders and discuss the current therapies approaches to it, which included pharmacological therapy, using Trazodone, Midazolam Maleate tablets, Gardenia Citrusaurantium capsules as well as non-pharmacological therapy, which use aerobic exercise and light therapy, promoting the idea of relieving sleep disorders as an adjunctive treatment for AD. The contents summarized in this paper have some significance of reference to the direction of treatment of AD sleep disorders.