Abstract
Platelet has been known to play a critical role in thrombosis and hemostasis. Increasing evidence from studies on bleeding or coagulation disorders demonstrates that platelet specific membrane receptor glycoprotein (GP)Ⅵ and GPⅠb subunit of GPⅠb-Ⅸ-Ⅴ complex are the main receptors regulating platelets' function (thrombosis and hemostasis). And abnormal expression or function of GPⅠb and GPⅥ are associated with many bleeding or coagulation disorders, suggesting the importance of these two receptors. Understanding the mechanisms of the regulation of GPⅠb and GPⅥ will be beneficial in the evaluation or prediction of the risk of thrombosis or bleeding in patients, which might provide guidance on the clinical treatment. This article reviews literatures on the structure, function and regulation of platelet receptors GPⅠb and GPⅥ, as well as their clinical significance in human diseases. Key words: Platelet membrane glycoprotein; Platelet activation; Hydrolysis
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