Abstract
Magnetic Particle Imaging (MPI) is a new generation of molecular imaging technology derived from Magnetic Resonance Imaging (MRI).It adopted complex combinations of rotary variable gradient magnetic field that can directly detect the Superparamagnetic Iron Oxide nanoparticles (SPIO) in vivo with high sensitivity of the Moore level. MPI is characterized by high temporal spatial resolution, high sensitivity, no scanning depth limitation and no ionizing radiation, etc. It has been applied in cell tracer,angiography,tumor imaging and treatment and other preclinical fields. Since its emergence in 2005, MPI has developed rapidly in software algorithms, hardware development, tracer design, and preclinical applications. Therefore, on the basis of briefly describing the history and basic principles of MPI, this article would summarize the research progress of MPI in cell tracer, blood vessel, tumor and other preclinical fields in recent years, and prospect the clinical transformation of MPI. Key words: Magnetic particle imaging; Superparamagnetic iron oxide nanoparticles; Molecular imaging; Tracer
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