Abstract
Platelet function testing is essential for the diagnosis of hemostasis disorders. While there are many methods used to test platelet function for research purposes, standardization is often lacking, limiting their use in clinical practice. Light transmission aggregometry has been the gold standard for over 60 years, with inherent challenges of working with live dynamic cells in specialized laboratories with independent protocols. In recent years, standardization efforts have brought forward fully automated systems that could lead to more widespread use. Additionally, new technical approaches appear promising for the future of specialized hematology laboratories. This review presents developments in platelet function testing for clinical applications.
Highlights
Over the last century, platelet function testing has undergone several transformations
This article presents recent developments in platelet function testing, and while it is difficult to predict which approaches will translate into widespread clinical hematology laboratory use, aspects of standardization, automation, and point-of-care devices will be highlighted
The standard in the identification and diagnosis of primary hemostatic defects, light transmission aggregometry (LTA) continues to be time, labour- and blood sample-intensive, rendering its use limited to specialized hematology laboratories
Summary
Platelet function testing has undergone several transformations. From the development of the Duke–Ivy bleeding time [1], to the invention of the light transmission aggregometer by Gus Born [2], to the newer high throughput advances in platelet function testing [3,4], capturing platelets in their natural ability to form aggregates in response to vascular injury remains a challenge. This article presents recent developments in platelet function testing, and while it is difficult to predict which approaches will translate into widespread clinical hematology laboratory use, aspects of standardization, automation, and point-of-care devices will be highlighted
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