Abstract
Organ transplant recipients (OTRs) are at significant risk for the development of nonmelanoma skin cancers (NMSC). NMSC and precursor lesions tend to be more numerous, diffusely located, recurrent, and aggressive in OTRs compared to immunocompetent patients. Not surprisingly, cutaneous malignancy is therefore a leading cause of morbidity and mortality in the OTR population. Given this significant disease burden, a great deal of interest has focused on the treatment and prevention of NMSC in OTRs. As a convenient and economical field-based therapy capable of treating large areas or multiple lesions simultaneously with excellent cosmetic outcomes, photodynamic therapy (PDT) is an attractive therapeutic option. Here we review the clinical data for the treatment and prevention of NMSC in OTR using PDT, including pretreatment and treatment considerations and associated risks.
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