Advances in Pharmacological Effects and Clinical Application of Pulsatilla Decoction

Abstract

Pulsatilla Decoction comes from treatise on febrile diseases. Its efficacy is to clear away heat, detoxify, cool blood and stop dysentery; In recent years, studies have found that the pharmacological effects and clinical applications of Pulsatilla decoction are diverse and extensive, with anti-inflammatory, bacteriostatic, antidiarrheal, antitumor and other effects. It is mainly used in ulcerative colitis, radiation proctitis, colorectal cancer, diarrhea, bacillary dysentery, anal sinusitis, anal recess inflammation and so on. This paper expounds its progress from the pharmacological action and clinical application of Pulsatilla decoction, in order to provide some experience for the further research of Pulsatilla decoction. Pulsatilla Decoction comes from Zhongjing's "Treatise on Febrile Diseases" [1]。Among them, "Treatise on Febrile Diseases • Differentiation and Treatment of Jueyin Pulse Syndrome" wrote: "Hot Li under the severe, Pulsatilla Decoction main." " Those who want to drink water because of the heat, the Pulsatilla soup is the main one. " It shows that the Pulsatilla Decoction is mainly used to treat heat and poison, and the characteristics of spleen and stomach deficiency and cold are contraindicated; This prescription is composed of four herbs, which are Pulsatilla, Huang Lian, Phellodendron, and Qinpi. The king medicine for Pulsatilla, the main effect is to clear heat and detoxify, cool blood dysentery. Huang Lian is the minister medicine, bitter cold sex taste, has the function of clearing heat and detoxifying, clearing heat and drying dampness; Phellodendron phellodendron has the effect of reducing coke and dampness and dysentery by combining with Coptis chinensis. Qinpi bitter cold astringent, strong astringent effect, often used for hemostasis. Combined with four drugs, it is a good prescription for treating heat poison blood dysentery. It is widely used in ulcerative colitis, colorectal cancer, bacillary dysentery, radiation proctitis, diarrhea caused by damp heat and other diseases. The progress of pharmacological research and clinical application of Pulsatilla Decoction on related diseases in recent five years is summarized as follows.