Advances in pathogenesis of chronic idiopathic thrombocytopenic purpura

Abstract

Idiopathic thrombocytopenic purpura （ITP）,as a heterogeneous autoimmune disease,is the most common bleeding disorder,of which etiology and pathogenesis are still unclear. Health related quality of life are severely affected,especally in chronic patients . Studys on chronic idiopathic thrombocytopenic purpura pathogenesis ,both in China and abroad,have found that genetic factors may be involved in the occurrence and prognosis of the disease. The paper gives a review from the follow aspects,such as its risk factors,relationship between genetic polymorphisms or expression levels and chronic ITP susceptibility and seriousness,the role of epigenetic,researchs about chronic and refractory ITP,et al. Key words: Chronic idiopathic thrombocytopenic purpura; Gene polymorphism; Gene expression; Epi-genetic