Abstract
Chronic refractory autoimmune thrombocytopenia (C/RITP) comprises complex and heterogeneous pathogenesis.Beyond the classic immune disorders such as platelet autoantibodies and cellular immune imbalance, other important considerations that can cause acquired C/RITP include infection, drug, vaccines, autoimmune diseases, tumor, or platelet function disorder.In addition, advances in the molecular mechanism and genetic correlations of C/RITP for children are also discussed. Key words: Chronic refractory autoimmune thrombocytopenia; Pathogenesis; Acquired; Genetic
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