Abstract
Parkinsons disease (PD) is an age-related neurodegenerative disease in which dopamine neu-rons in the substantia nigra of the brain gradually die over time. PD mainly manifests as rest-ing tremor, bradykinesia, stiffness, and ultimately the inability to control motor function and cause severe disability. It has now been shown that neuronal Lewy bodies (LBs) and the intra-synaptic aggregation of Synuclein (Syn) are hallmarks of brain lesions in PD, and Lewy body lesions have been found to be present in the peripheral nervous system in PD. Interfer-ing with LBs formation has become a new hot topic in Parkinson's disease treatment. The formation of LBs has been linked to the transport of Syn in brain cells and the blood-brain barrier. Nonetheless, treatment options still produce little effect. According to past investiga-tions, this paper addresses the question of advances in pathogenesis and treatment of Parkin-sons disease using literature review as an investigation method. It introduces the pathogene-sis and the latest treatment strategies of PD based on the aspect of abnormal accumulation of Syn, which can provide a theoretical basis for subsequent treatment of PD.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
