Advances in Pathogenesis and Treatment of Parkinsons Disease Based on Abnormal Accumulation of Alpha-Synuclein

Abstract

Parkinsons disease (PD) is an age-related neurodegenerative disease in which dopamine neu-rons in the substantia nigra of the brain gradually die over time. PD mainly manifests as rest-ing tremor, bradykinesia, stiffness, and ultimately the inability to control motor function and cause severe disability. It has now been shown that neuronal Lewy bodies (LBs) and the intra-synaptic aggregation of Synuclein (Syn) are hallmarks of brain lesions in PD, and Lewy body lesions have been found to be present in the peripheral nervous system in PD. Interfer-ing with LBs formation has become a new hot topic in Parkinson's disease treatment. The formation of LBs has been linked to the transport of Syn in brain cells and the blood-brain barrier. Nonetheless, treatment options still produce little effect. According to past investiga-tions, this paper addresses the question of advances in pathogenesis and treatment of Parkin-sons disease using literature review as an investigation method. It introduces the pathogene-sis and the latest treatment strategies of PD based on the aspect of abnormal accumulation of Syn, which can provide a theoretical basis for subsequent treatment of PD.