Abstract
This review paper focuses on recent progress in optical biosensors using self-ordered nanoporous anodic alumina. We present the fabrication of self-ordered nanoporous anodic alumina, surface functionalization, and optical sensor applications. We show that self-ordered nanoporous anodic alumina has good potential for use in the fabrication of antibody-based (immunosensor), aptamer-based (aptasensor), gene-based (genosensor), peptide-based, and enzyme-based optical biosensors. The fabricated optical biosensors presented high sensitivity and selectivity. In addition, we also showed that the performance of the biosensors and the self-ordered nanoporous anodic alumina can be used for assessing biomolecules, heavy ions, and gas molecules.
Highlights
We address some of the most recent papers that prove that various optical biosensors andof the sections, first, we explain the electrochemical fabrication and functionalization sensors made suchofasthe immunosensors, aptasensors, enzyme-based sensors, gasbiosensors sensors, nanoporous anodic alumina (NAA). are
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Detailed information was presented about the fabrication, structure, surface modification, This review article highlights recent advances in optical biosensors based on nanoporous anodic and biosensing properties of nanoporous anodic alumina
Summary
Three-dimensional nanostructures offer a new chance for researchers in the field of nanoscience to improve the performance of biodevices [1,2,3]. Theoxide, effective index is and a function of the different refractive composing thin the liquid different molecules attach to the pore surfaces, refractive index film: the medium oxide, theand filling medium, and the attached molecules. The effective refractive index is a function of the liquid medium and different molecules attach to the pore surfaces, the effective refractive index different composing theFP thin film: the the refractive filling medium, and the attached changes,refractive causing aindices resulting shift in the fringes. Weusing address some most recent papers that prove that various optical and sensors are made using NAA such as immunosensors, aptasensors, enzyme-based sensors, gas sensors, smalll biomolecule sensors, and ion sensors We discuss their structure, surface functionalization, andWe performance suchsurface as sensitivity, range of smalll biomolecule method sensors, of anddetection, ion sensors. Method detection, performance parameters such as sensitivity, range of linearity, and limit of detection
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