Abstract
Ribonucleotide reductase (RR) is a rate-limiting enzyme, and it is responsible for reducing ribonucleotides to their corresponding deoxyribonucleotides, which are the building blocks required for DNA replication and repair. Recent studies have revealed that RR activity is associated with DNA replication in virus, and RR inhibitors have been used for clinical antiviral treatment. This paper reviews research progress on RR and its inhibitors, including the classification, structure and function of RR; the classification, mechanism and clinical application of RR inhibitors in antiviral therapy and the future prospects of RR inhibitors. Key words: Ribonucleotide reductases; Enzyme inhibitors; Antiviral treatment; Clinical application
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