Abstract
Advances in non-coding RNA profiling for neurological diseases
Highlights
One of the challenges with the emerging field of ncRNAs is the frequent updates to the current database of annotated transcripts and occasional changes in nomenclature, making it essential to keep current with available sequence information
Postmortem miRNA profiling in schizophrenia has revealed significant changes associated with the disorder (Perkins et al, 2007; Beveridge et al, 2008, 2010; Santarelli et al, 2011)
The extent of amplification will depend both on the sensitivity of the instrumentation and the amount of RNA that can be devoted to ncRNA analysis
Summary
One of the challenges with the emerging field of ncRNAs is the frequent updates to the current database of annotated transcripts and occasional changes in nomenclature, making it essential to keep current with available sequence information. The miRBase server, which contains all annotated miRNAs, has already been updated through 19 different versions to date. Technology suppliers usually lag behind databases with their ncRNA platforms, some have the capacity to include custom content if required for a particular study.
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