Abstract
During the last two decades, there has been broad interest in RNA-based technologies for the development of prophylactic and therapeutic vaccines. Preclinical and clinical trials have shown that mRNA vaccines provide a safe and long-lasting immune response in animal models and humans. In this review, we summarize current research progress on mRNA vaccines, which have the potential to be quick-manufactured and to become powerful tools against infectious disease and we highlight the bright future of their design and applications.
Highlights
Vaccination is the most successful medical approach to disease prevention and control
Lipid nanoparticles (LNP) loaded with nucleoside modified conventional mRNA encoding firefly luciferase have been used, for example, to mRNA Vaccine Against Infectious Diseases examine the influence of route of administration on kinetics of antigen expression [94]. i.m. and i.d. injections offered the best levels and duration of effect, with protein production peaking at 4 h and maintained locally 8–10 days post injection, depending on the dose
Geall and colleagues showed that i.m. administration in mice and cotton rats with very low dose of self-amplifying mRNA encoding the F protein of respiratory syncytial virus (RSV) encapsulated with a synthetic lipid nanoparticle (LNP) induced very high titers of IgG1 and interferon (IFN)-producing CD4 and CD8 T cells [22]
Summary
Vaccination is the most successful medical approach to disease prevention and control. MRNA vaccines expressing antigen of infectious pathogen induce both strong and potent T cell and humoral immune responses [8, 16, 19].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
