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Abstract
The microbiome, as a community of microorganisms and their structural elements, genomes, metabolites/signal molecules, has been shown to play an important role in human health, with significant beneficial applications for gut health. Skin microbiome has emerged as a new field with high potential to develop disruptive solutions to manage skin health and disease. Despite an incomplete toolbox for skin microbiome analyses, much progress has been made towards functional dissection of microbiomes and host-microbiome interactions. A standardized and robust investigation of the skin microbiome is necessary to provide accurate microbial information and set the base for a successful translation of innovations in the dermo-cosmetic field. This review provides an overview of how the landscape of skin microbiome research has evolved from method development (multi-omics/data-based analytical approaches) to the discovery and development of novel microbiome-derived ingredients. Moreover, it provides a summary of the latest findings on interactions between the microbiomes (gut and skin) and skin health/disease. Solutions derived from these two paths are used to develop novel microbiome-based ingredients or solutions acting on skin homeostasis are proposed. The most promising skin and gut-derived microbiome interventional strategies are presented, along with regulatory, safety, industrial, and technical challenges related to a successful translation of these microbiome-based concepts/technologies in the dermo-cosmetic industry.
Highlights
Applications of Microbiome sciences are very large and have been proposed as a potential target solution for the 21st century socio-economic and environmental challenges [1]
These metabolomic applications have led to the identification of important bacterial-based targets for disease diagnosis and treatment, inspiring the use of metabolomic approaches to characterize the molecules associated with the skin microbiome and to explore their role in influencing skin physiology [144]
Research is at the dawn of a «new generation» cosmetic that will use the skin’s microbiome to provide lasting products with new efficient performance
Summary
Applications of Microbiome sciences are very large and have been proposed as a potential target solution for the 21st century socio-economic and environmental challenges [1]. Scientists have been interested in the microbiome and its impact on human health. A major focus was put on the gut microbiome, and its role in human health has been well established [2]. Oral cavity, and skin microbiome is beginning to emerge [3]. A deeper knowledge of the microbiome, that of the skin, opens perspectives for a revolution in dermo-cosmetic development. These recent discoveries have changed our perception of the role of bacteria in skin health. Protect or rebalance the skin microbiome are a new trend in the dermo-cosmetic industry
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