Abstract
This review gives an updated overview on keratinocyte transplantation in burn wounds concentrating on application methods and future therapeutic cell delivery options with a special interest in hydrogels and spray devices for cell delivery.To achieve faster re-epithelialisation of burn wounds, the original autologous keratinocyte culture and transplantation technique was introduced over 3 decades ago. Application types of keratinocytes transplantation have improved from cell sheets to single-cell solutions delivered with a spray system. However, further enhancement of cell culture, cell viability and function in vivo, cell carrier and cell delivery systems remain themes of interest.Hydrogels such as chitosan, alginate, fibrin and collagen are frequently used in burn wound care and have advantageous characteristics as cell carriers.Future approaches of keratinocyte transplantation involve spray devices, but optimisation of application technique and carrier type is necessary.
Highlights
Burn injuries are complicated wounds to manage with a relative high mortality rate in especially large area burns and elderly patients [1]
Keratinocytes play a vital role in especially the proliferative phase of burn wound healing leading to epithelialisation and restoration of the vascular network
To achieve faster re-epithelialisation, keratinocyte transplantation was introduced as part of the burn wound care arsenal over 30 years ago
Summary
Burn injuries are complicated wounds to manage with a relative high mortality rate in especially large area burns and elderly patients [1]. Functional and aesthetic outcome of the restored tissue are reflected by scar quality in terms of pigmentation, pliability, sensation, hair growth and function (prevention of scar contraction). All of these factors require a specialized approach aiming on regeneration of tissue instead of tissue repair. Advances of long term results are desired to facilitate the need for quality of life improvement of the increasing population of burn survivors. Answers to these challenges are sought in the field of tissue engineering. This review gives an updated overview on applications of keratinocyte delivery in burns and wound healing and future therapeutic cell delivery options with a special interest in hydrogels and spray devices for cell delivery
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